Merrifield Resin

Merrifield resin is one of the standard supports for the synthesis of peptides by Boc strategy.

Originally, the cesium salt of a protected amino acid was anchored to the chloromethyl supporvia nucleophilic displacement of chlorine.

Cleavage has been performed with Hydrofluoric acid or trifluoromethanesulfonic acid or by catalytic transfer hydrogenolysis,

alcohols can be released by using diisobutylaluminium hydride or LiBH.New isomeric

trialkoxybenzylamineresins have been developed by coupling phthalimidomethyl-3,5-dimethoxyphenols to this resin followed by subsequent treatment with hydrazine, that allows DCC coupling with the carboxyifunction of amino acids or peptides.